Isifo senhliziyo, okuyimbangela ehamba phambili yokufa kwezifo ezingathathelaniyo, ikakhulukazi isifo esihlobene nokuguga.Ngokukhula kweminyaka, inhliziyo, njengesitho esimpompa igazi, izoguga, futhi ikhono layo lokukhululeka kanye nenkontileka lizokwehla, futhi kancane kancane ngeke ikwazi ukumpompa igazi emzimbeni wonke, okuzogcina kuholele ekuhlulekeni kwenhliziyo. iziguli futhi kuthinte kakhulu impilo enempilo yabantu.
Ukuguga kwenhliziyo kubonakala ngokuncipha kokuvumelana kwenhliziyo (ukusebenza kwenhliziyo), okuzohambisana nokuncipha kobuningi bamaprotheni kanye nezinguquko zokuguqulwa kwamaprotheni ngemva kokuhumusha.
I-SS-31 peptide iyi-cardiolipin peroxidase inhibitor kanye ne-mitochondrial targeting peptide.Ingathuthukisa ukusebenza kwe-ventricle yesokunxele kanye ne-mitochondria.I-SS-31 peptide ingadambisa ukungasebenzi kahle kwe-mitochondrial kanye nokulimala kwe-oxidative kumaseli e-trabecular meshwork womuntu.Ingavimbela amaseli e-iHTM kanye ne-GTM(3) ekucindezelekeni okuqhubekayo kwe-oxidative okubangelwa i-H2O2.
I-SS-31 iyisithako se-mitochondrial esiqondise ukulwa nokuguga, okubonakale sisebenza ngempumelelo ekubuyiseleni ukusebenza kwenhliziyo kwamagundane asebekhulile.I-tetrapeptide yokwenziwa ehlanganiswe ne-membrane yangaphakathi ye-mitochondrial, engathuthukisa umsebenzi we-mitochondrial, inciphise ukukhiqizwa kwezinhlobo ze-oksijini esebenzayo i-ROS, inciphise izinga lezinto ezibangela ukuvuvukala futhi ikakhulukazi ithuthukise umsebenzi we-diastolic wenhliziyo.
Okokuqala, ukuqhathanisa amagundane amancane namagundane amadala, ososayensi bathola ukuthi ukuchichima kwamaprotheni e-mitochondrial kuthinteka ikakhulukazi ukuguga, kuhlanganise nendlela yokudlulisa isignali ye-mitochondrial, amaprotheni ahlobene nendlela ye-oxidative phosphorylation ekhiqiza amandla, kanye namaprotheni ahlobene nendlela yokudluliselwa kwesignali ye-SIRT ehlobene namandla. I-metabolism ku-mitochondria.Ngaphezu kwalokho, amaprotheni abalulekile i-troponin ne-tropomyosin, axhumanisa ngokuqondile ukufinyela kwe-myocardial, nawo ngokusobala athinteka ukuguga.Lezi zihlobene eduze nokusebenza kwenhliziyo.Okwesibili, lapho kucatshangelwa ithonya lokwelashwa kwe-SS-31, abacwaningi bathola ukuthi ubuningi bamaprotheni amagundane amadala aphathwayo abubonakali buhambisana neqembu elincane, kodwa bonke babonisa ukubuyiselwa kwendlela yokungasebenzi ngokuguga, njengokuchichima kwamaprotheni omjikelezo we-tricarboxylic acid, indlela eyinhloko yokukhiqiza amandla emzimbeni, eyalulama ngempela ngokwezinga elikhulu, okwenza amagundane amadala abe mancane.Lokhu kusho ukuthi i-SS-31 isebenza ngokukhethekile ekushintsheni amandla e-metabolism okubangelwa ukuguga kwenhliziyo.Ukuhlolwa kobuningi bamaprotheni kwafika esiphethweni, ngemva kwalokho abacwaningi babheka izinguquko zokuguqulwa kwamaprotheni ngemva kokuhumusha phakathi nenqubo yokuguga, futhi bakhetha ngokukhethekile ukuguqulwa okuvame kakhulu ngemva kokuhumusha kumaprotheni, okuhlobene kakhulu nenhliziyo. - ukuguqulwa kwe-acetylation.Kungase kube nezinguquko ezimbili ekuguqulweni kwe-acetylation.Okokuqala, ngenxa yokuthi i-acetylation ye-protein ye-mitochondrial izokhula ngokukhula, okuholela ekungasebenzi kahle kwe-mitochondrial, futhi okuqukethwe kwe-mitochondrial kwenhliziyo kuphakeme kakhulu, ngakho-ke yonke inhliziyo ingaba nokuqoqwa kwe-acetylation ephezulu ngenkathi umsebenzi wenhliziyo wehla;Okwesibili, kuzoba nokulahlekelwa kwe-acetylation evamile yezinsalela ezithile ekugugeni, okuzoholela ekuhlulekeni kokudlala umsebenzi wayo ovamile.Abacwaningi baye bacebisa ama-peptide ane-acetylated enhliziyweni (okungamane kuqondwe njengamayunithi amancane asetshenziselwa ukwakha amaprotheni).Kusenomehluko esimweni se-acetylation samaprotheni enhliziyo phakathi kweqembu elincane neqembu elidala, kodwa akubonakali njengobuningi bamaprotheni.Khona-ke baphinde bahlole ukuthi yimaphi amaprotheni lolu shintsho esimweni se-acetylation lungacacisa.Ekugcineni, abacwaningi baphinde baxhumanisa ikhono le-systolic ne-diastolic yenhliziyo futhi bathola izindawo ze-acetylation ze-14 ezihlobene nekhono le-diastolic lenhliziyo, futhi zonke zazihlotshaniswa kabi.Ngesikhathi esifanayo, amasayithi amabili ahlobene ne-contractility yenhliziyo nawo atholakala.Lokhu kusho ukuthi ukuguqulwa kwenkontileka ngesikhathi sokuguga kungase kulawulwe isimo se-acetylation seprotheni yenhliziyo.
Singumkhiqizi we-polypeptide e-China, esineminyaka eminingana yokuhlangenwe nakho okuvuthiwe ekukhiqizeni i-polypeptide.I-Hangzhou Taijia Biotech Co., Ltd. ingumkhiqizi wezinto ezingavuthiwe ze-polypeptide, enganikeza amashumi ezinkulungwane zezinto zokusetshenziswa ze-polypeptide futhi ingenziwa ngokwezifiso ngokwezidingo.Izinga lemikhiqizo ye-polypeptide lihle kakhulu, futhi ubumsulwa bungafinyelela ku-98%, okuye kwaqashelwa abasebenzisi emhlabeni wonke.Siyakwamukela ukuthi uxhumane nathi.
