I-Peptide iyinhlanganisela ye-organic, ephelelwa amanzi kuma-amino acid futhi iqukethe amaqembu e-carboxyl nama-amino.Kuyinhlanganisela ye-amphoteric.I-Polypeptide iyinhlanganisela eyakhiwe ama-amino acid axhunywe ndawonye ngamabhondi e-peptide.Kungumkhiqizo ophakathi nendawo we-protein hydrolysis.Yakhiwa ukuphelelwa amanzi emzimbeni kanye nokufingqa kwama-amino acid ayi-10 ~ 100, futhi isisindo sayo samangqamuzana singaphansi kuka-10000Da.Ingangena kulwelwesi olungena kancane futhi ayincishiswa yi-trichloroacetic acid ne-ammonium sulfate, okuhlanganisa nama-peptide e-bioactive nama-peptide okwenziwa okwenziwa.
Izidakamizwa ze-Polypeptide zibhekisela kuma-polypeptide anemiphumela ethile yokwelapha ngokusebenzisa ukuhlanganiswa kwamakhemikhali, ukuhlanganiswa kabusha kwezakhi zofuzo kanye nokukhipha isilwane nezitshalo, ezihlukaniswe ikakhulukazi ama-polypeptides angapheli (njenge-enkephalin ne-thymosin) namanye ama-polypeptide angaphandle (njengobuthi benyoka ne-asilic acid).Isisindo samangqamuzana esihlobene sezidakamizwa ze-polypeptide siphakathi kwezidakamizwa zamaprotheni nezidakamizwa ezincane, ezinobuhle bezidakamizwa ze-micromolecule nezidakamizwa zamaprotheni.Uma kuqhathaniswa nezidakamizwa ze-micromolecule, izidakamizwa ze-polypeptide zinomsebenzi ophezulu wezinto eziphilayo kanye nokucaciswa okuqinile.Uma kuqhathaniswa nemithi yamaprotheni, izidakamizwa ze-polypeptide zinokuzinza okungcono, ukuzivikela komzimba okuphansi, ukuhlanzeka okuphezulu kanye nezindleko eziphansi uma kuqhathaniswa.
I-Polypeptide ingamuncwa umzimba ngokuqondile futhi ngenkuthalo, futhi isivinini sokumuncwa siyashesha, futhi ukumuncwa kwe-polypeptide kubaluleke kakhulu.Ngaphezu kwalokho, ama-peptides awakwazi nje ukuthwala izakhi, kodwa futhi adlulisele ulwazi lwamaselula ukuze ayale izinzwa.Izidakamizwa ze-Polypeptide zinezici zomsebenzi ophezulu, ukukhetha okuphezulu, ubuthi obuphansi kanye nokuhlotshaniswa okuphezulu okuhlosiwe, kodwa ngesikhathi esifanayo, nazo zinezinkinga ze-half-life short, ukungasebenzi kahle kwe-cell membrane kanye nomzila owodwa wokuphatha.
Ngokubheka ukushiyeka kwezidakamizwa ze-polypeptide, abacwaningi benze imizamo engapheli emgwaqeni wokuthuthukisa ama-peptide ukuthuthukisa i-bioavailability yezidakamizwa ze-polypeptide.Ukujikeleza kwama-peptide kungenye yezindlela zokwandisa ama-peptide, futhi ukuthuthukiswa kwama-peptide angama-cyclic kulethe ukusa emithini ye-polypeptide.Ama-cyclic peptide anenzuzo emithini ngenxa yokuzinza kwawo okuhle kakhulu kwe-metabolic, ukukhetha nokuhambisana, ukufinyeleleka kolwelwesi lwamaseli kanye nokutholakala komlomo.Ama-cyclic peptide anemisebenzi yebhayoloji efana nokulwa nomdlavuza, ukulwa nokutheleleka, ukulwa nesikhunta kanye ne-anti-virus, futhi angama-molecule ezidakamizwa athembisa kakhulu.Eminyakeni yamuva nje, izidakamizwa ze-cyclic peptide zidonse ukunaka okukhulu, futhi izinkampani ezenza imithi zilandele umkhuba wokuthuthukiswa kwezidakamizwa ezintsha futhi zabeka amathrekhi ezidakamizwa ze-cyclic peptide ngokulandelana.
UDkt. Chen Shiyu ovela e-Shanghai Institute of Pharmacology, i-Chinese Academy of Sciences wethula imithi ye-cyclic peptide egunyazwe kusukela ngo-2001 kuya ku-2021 emithini yayo ye-cyclic peptide egunyazwe emithini emibili yokugcina.Eminyakeni engu-20 edlule, kunezinhlobo ezingu-18 zezidakamizwa ze-cyclic peptide emakethe, phakathi kwazo inani lama-peptide angama-cyclic asebenza ku-cell wall synthesis kanye ne-β-1,3- glucanase targets inkulu, enezinhlobo ezi-3 iyinye.Imithi evunyelwe ye-cyclic peptide ihlanganisa ukulwa nokutheleleka, i-endocrine, uhlelo lokugaya ukudla, i-metabolism, isimila/ukuzivikela komzimba kanye nesimiso sezinzwa esimaphakathi, phakathi kwazo izidakamizwa ezilwa nokutheleleka kanye ne-endocrine cyclic peptide zenza ama-66.7%.Mayelana nezinhlobo ze-cyclic peptide, kunezidakamizwa eziningi ze-cyclic peptide ezihanjiswa ngamabhondi e-disulfide futhi ziqhutshwa ngamabhondi e-amide, kanye nezidakamizwa ezingu-7 nezingu-6 zagunyazwa ngokulandelanayo.
Isikhathi sokuthumela: Sep-18-2023