Kujusi yesisu somuntu, i-BPC 157 izinzile isikhathi esingaphezu kwamahora angu-24, futhi ngaleyo ndlela ine-bioavailability yomlomo (ehlala inikezwa yedwa) kanye nemiphumela enenzuzo kuwo wonke umgudu wamathumbu.Lona umehluko obalulekile kusukela kwamanye ama-peptide ajwayelekile, ancike ngokusebenza ekwengezweni kwenkampani noma abhujiswa ngokushesha kujusi yesisu somuntu. Ngenxa yalokho, i-BPC 157 ezinzile iphakanyiswa ukuthi ibe umlamuli we-Robert's cytoprotection, egcina ubuqotho ogastrointestinal mucosa.Siphakamisa ukuthi umnikelo we-BPC 157 ku-cytoprotection kaRobert - okungukuthi, amandla okulwa nezilonda eziyisisekelo ezibangelwa utshwala, u-Robert azibiza ngokuthi i-cytoprotection - kanye nekhono lokubhekana nezilonda ezivela ekuthinteni okulimazayo okuqondile kwe-ejenti eyingozi neseli. imele ukuxhumana kwe-peripheral phakathi kwamathumbu kanye ne-axis yobuchopho.
U-Perovic ubike ukuthi i-BPC 157 inomphumela ophawulekayo wokwelapha ophathelene nokubuyiselwa kwamagundane ngokulimala komgogodla ngokukhubazeka komsila (ukulimala kokucindezela kweminithi elingu-1 lomgogodla we-sacrocaudal [S2-Co1]).Ngokuqondile, ukuphathwa kwe-intraperitoneal BPC 157 eyodwa emaminithini we-10 ngemuva kokulimala kuphikisa imiphumela emibi.Ngokuphambene nalokho, ukulimala komgogodla kanye nokukhubazeka komsila kuqhubeka kumagundane angaphenduliwe, izinsuku ezihlolwe, amasonto, izinyanga, nonyaka ngemva kokulimala.Qaphela, i-BPC 157 inciphisa umonakalo ovame ukubangelwa .Ngaleyo ndlela, ukwelashwa kwe-BPC 157 kuphumela ekululameni okusobala kokusebenza, okungabonakali, kanye nokululama kwe-electrophysiologic.
Okuqaphelekayo, kumagundane anokulimala komgogodla, kukhona ukuphindaphinda unomphela.Uma i-BPC 157 ilawulwa imizuzu engu-10 yokulimala ngemva kokucindezelwa, kukhona ukuvikeleka okuqhubekayo futhi akukho ukuphazamiseka okubangelwa ukulimala komgogodla okuzenzakalelayo okuphinde kuvele.Konke ukulimala komgogodla ngokushesha kubangele ukopha, nokufa okulandelayo kwama-neurons nama-oligodendrocyte.
Ngakho-ke, kucatshangwa ukuthi i-hemostasis yokuqala ingase ibe yinzuzo futhi inike amandla ukutakula okusebenzayo ngemva kokuphazamiseka kwentambo yomgogodla kumagundane.Nokho, umphumela owenziwe yi-BPC 157 cishe uhlukile kumphumela olula we-hemostatic onganciphisa ukulimala komgogodla, ngoba i-BPC 157 iphinde ithuthukise ngokuphawulekayo ukusebenza kwe-thrombocyte kumagundane ngaphandle kokuthinta izici zokuhlangana.Ngesikhathi sokululama ekulimaleni komgogodla, i-BPC 157 iphinde ivikele ngokuqondile i-endothelium, inciphise ukuphazamiseka kwe-vascular occlusion ye-peripheral, isebenze ngokushesha ezinye izindlela ze-bypass, futhi iphikisana ne-syndromes ye-venous occlusion-induced.Ngakho-ke, kucatshangwa ukuthi kunomnikelo omkhulu we-venous ekucindezelweni komgogodla, kucatshangwa ukuthi ukugeleza kwegazi okusungulwe kabusha okuxhunywe yi-BPC 157 ngokungangabazeki kungase kube nomthelela emphumeleni wokubuyisela ngokushesha.Ngaphezu kwalokho, uma kucatshangelwa ukuthi i-BPC 157 ikhuthaza ukubuyisela kabusha unomphela ngemva kokucindezelwa kwentambo yomgogodla, kufanele kuqashelwe ukuthi uma i-BPC 157 inikezwa ngesikhathi sokuphindaphinda, iphikisana nokushaywa yi-stroke okubangelwa ukugoqa okubili kwe-arteries evamile ye-carotid.I-BPC 157 ixazulula ukulimala kwe-neuronal futhi ivimbele inkumbulo, i-locomotor, nokushoda kokuxhumana.I-BPC 157 ngokusobala isebenzisa le miphumela ngokushintsha ukubonakaliswa kofuzo ku-hippocampus .
Sengiphetha, i-BPC 157 inemiphumela enenzuzo ku-stroke, i-schizophrenia, nokulimala komgogodla.
Abacwaningi baye babonisa ngokungaguquki ukuthi i-BPC 157 inemiphumela eminingi enenzuzo kuwo wonke umzimba.Asikho isizathu sokukhombisa ukuthi izinzuzo ze-BPC 157 zikhawulelwe ukufaneleka kwamamodeli asetshenzisiwe kanye/noma imikhawulo yendlela yokusebenza.Ngempela, singaphikisana ngokuthi ukusebenza kahle, ukusebenziseka kalula, iphrofayili yomtholampilo ephephile kanye nendlela ye-BPC 157 kumelela enye indlela, okungenzeka ibe yimpumelelo, isiqondiso sokwelapha esizayo sezimo zemizwa.Ngakho-ke, ucwaningo olwengeziwe luyadingeka ukuze kucaciswe ukuthi ukwelapha okungaba khona kwe-BPC 157 kungabhekana kanjani ngokuqondile nendlela yesenzo ebandakanya amasayithi amaningi angaphansi kwamaselula ku-CNS.Umthelela ekusebenzeni kweziningi, uma kungezona zonke, izinhlelo ze-neuronal ezingeni lamangqamuzana, amaselula, kanye nesistimu kufanele ihlolwe.Okunye okuphindaphindwayo kwe-visceral kwe-CNS noma izitho eziyisiyingi, okungenye yezifunda ezimbalwa ebuchosheni ngaphandle komgoqo wobuchopho begazi, kuyindlela eyaziwayo lapho i-peptide elawulwa ngohlelo ingaba nomthelela omaphakathi.Ngakho, kufanele isebenze ngaphakathi kwe-axis ye-gut-brain, kungakhathaliseki ukuthi lesi senzo siqondile noma asiqondile.
